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   Official Journal of The Academy of Osseointegration

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Volume 25 , Issue 1
January/February 2005

Pages 4959

A Reentry Study on the Use of Bovine Porous Bone Mineral, GTR, and Platelet-Rich Plasma in the Regenerative Treatment of Intrabony Defects in Humans

Paulo M. Camargo, DDS, MS/Vojislav Lekovic, DDS, PhD/Michael Weinlaender, MD, DDS/Nikola Vasilic, DDS/Milovan Madzarevic, DDS, MS/E. Barrie Kenney, BDSc, DDS, MS

PMID: 15736778
DOI: 10.11607/prd.00.0614

This study compared the clinical effectiveness of a combination therapy consisting of bovine porous bone mineral (BPBM), guided tissue regeneration (GTR), and platelet-rich plasma (PRP) in the regeneration of periodontal intrabony defects in humans. Twenty-eight paired intrabony defects were surgically treated using a split-mouth design. Defects were treated with BPBM, GTR, and PRP (experimental), or with open-flap debridement (control). Clinical parameters evaluated included changes in attachment level, pocket depth, and defect fill as revealed by reentry at 6 months. Preoperative pocket depths, attachment levels, and transoperative bone measurements were similar for the two groups. Postsurgical measurements taken at 6 months revealed that both treatment modalities significantly decreased pocket depth and increased clinical attachment and defect fill compared to baseline. The differences between the experimental and control groups were 2.22 0.39 mm on buccal and 2.12 0.34 mm on lingual sites for pocket depth, 3.05 0.51 mm on buccal and 2.88 0.46 mm on lingual sites for gain in clinical attachment, and 3.46 0.96 mm on buccal and 3.42 0.02 mm on lingual sites for defect fill. These differences between groups were statistically significant in favor of the experimental defects. The combined therapy was also clinically more effective than open-flap debridement. The superiority of the experimental group could not be attributed solely to the surgical intervention and was likely a result of the BPBM/GTR/ PRP application. Combining BPBM, GTR, and PRP was an effective modality of regenerative treatment for intrabony defects in patients with advanced periodontitis. (Int J Periodontics Restorative Dent 2005;25:4959.)

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