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Volume 35 , Issue 6
November/December 2015

Pages 825–833


Platelet-Derived Growth Factor–Mediated Guided Bone Regeneration in Immediate Implant Placement in Molar Sites with Buccal Bone Defects

Ronaldo B. Santana, DDS, MScD, DSc/Carolina M.M. Santana, DDS, MScD, DScD/Serge Dibart, DDS, MScD


PMID: 26509986
DOI: 10.11607/prd.2330

This study compared the clinical outcomes of recombinant human plateletderived growth factor BB and beta-tricalcium phosphate (rhPDGF-BB/βTCP) with guided bone regeneration (GBR) in immediate implant placement in molar extraction sockets with buccal bone defects versus conventional implant placement. Twenty-eight implants were placed in fourteen patients. Clinical and radiographic evaluations assessed peri-implant soft and hard tissue parameters after 12 months. No implants were lost during the 1-year observation period, yielding a survival rate of 100%. Similar clinical and radiographic parameters were observed for both treatment groups. Use of rhPDGF-BB/βTCP and GBR in immediate implants in molars was as successful as conventional implant placement in fully healed extraction sites.


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