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Volume 34 , Issue 6
November/December 2019

Pages 1389–1396


Effect of Strontium-Coated Titanium Implants on Osseointegration in Animal Models: A Literature Systematic Review

Nansi López-Valverde, MS/Jorge Muriel-Fernández, PhD/Rafael Gómez de Diego, PhD/Juan M. Ramírez, PhD/Antonio López-Valverde, DDS, PhD


PMID: 31711080
DOI: 10.11607/jomi.7827

Purpose: This study represents a systematic review of the literature to assess the effectiveness of strontium-coated titanium surfaces on osseointegration in experimental assays with healthy, nonosteoporotic and/or nonosteopenic animals. Materials and Methods: An electronic search was conducted of the databases MEDLINE/PubMed, Wiley Library, and Web of Science through 2018, with the aim of identifying studies on the osseointegration of titanium implants modified with strontium. Results: A total of 255 papers were found, of which 11 were included in this systematic review. The primary result was the percentage of bone-to-implant contact (BIC) around the titanium implants with or without a strontium-coated surface. The different techniques used to coat titanium surfaces with strontium recorded significant results in terms of the improvement in the implant’s quality, as they increased its contact with the bone, bone area, and bone formation, as well as enhanced its biomechanical properties. Conclusion: Nine of 11 studies reported that titanium implants coated with strontium showed significantly higher BIC (P < .001 to P < .05). This coating also improved the implants’ biomechanical properties.


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