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Volume 29 , Issue 6
November/December 2014

Pages 1429–1434

Body Fat Indices and Biomarkers of Inflammation: A Cross-Sectional Study with Implications for Obesity and Peri-implant Oral Health

Satheesh Elangovan, BDS, DSc, DMSc/Kim A. Brogden, PhD/Deborah V. Dawson, ScM, PhD/Derek Blanchette, MS/Keyla Pagan-Rivera, MS/Clark M. Stanford, DDS, PhD/Georgia K. Johnson, DDS, MS/Erica Recker, BS/Rob Bowers, BS/William G. Haynes, MD/Gustavo Avila-Ortiz, DDS, MS, PhD

PMID: 25397806
DOI: 10.11607/jomi.3758

Purpose: To examine the relationships between three measures of body fat—body mass index (BMI), waist circumference (WC), and total body fat percent—and markers of inflammation around dental implants in stable periodontal maintenance patients. Materials and Methods: Seventy-three subjects were enrolled in this cross-sectional assessment. The study visit consisted of a physical examination that included anthropologic measurements of body composition (BMI, WC, body fat %); intraoral assessments were performed (full-mouth plaque index, periodontal and peri-implant comprehensive examinations) and peri-implant sulcular fluid (PISF) was collected on the study implants. Levels of interleukin (IL)-1α, IL-1β, IL-6, IL-8, IL-10, IL-12, IL-17, tumor necrosis factor-α, C-reactive protein, osteoprotegerin, leptin, and adiponectin in the PISF were measured using multiplex proteomic immunoassays. Correlation analysis with body fat measures was then performed using appropriate statistical methods. Results: After adjustments for covariates, regression analyses revealed statistically significant correlation between IL-1β in PISF and WC (R = 0.33; P = .0047). Conclusion: In this study in stable periodontal maintenance patients, a modest but statistically significant positive correlation was observed between the levels of IL-1β, a major proinflammatory cytokine in PISF, and WC, a reliable measure of central obesity.

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