New and innovative biomaterials are being discovered or created in laboratories at an unprecedented rate, but many of them remain entirely foreign to practicing clinicians. This book addresses this gap in knowledge by summarizing some of the groundbreaking research performed to date on this topic and providing case examples of these biomaterials at work. The book begins with a review of the biologic background and applications of bone grafting materials utilized in dentistry. The principles of guided tissue and bone regeneration are covered in detail, including many recent advancements in barrier membrane technologies as well as use of platelet-rich fibrin and various growth factors, and many next-generation materials that will optimize future bone and periodontal regeneration are presented. The final chapter is designed to help clinicians select appropriate biomaterials for each specific regenerative protocol. Much like one implant size and shape cannot be utilized for every indication in implant dentistry, one bone grafting material, barrier membrane, or growth factor cannot maximize regenerative outcomes in all clinical situations. This textbook teaches clinicians how to utilize biomaterials in an appropriate, predictable, and evidence-based manner.

384 pp; 960 illus;

ISBN: 978-0-86715-796-3; 9780867157963;

Contents
1. The Regenerative Properties of Bone Grafts: A Comparison Between Autografts, Allografts, Xenografts, and Alloplasts
Richard J. Miron and Yufeng Zhang
2. Autogenous Bone: The Gold Standard for Bone Regeneration
Richard J. Miron, Homayoun H. Zadeh, Tobias Fretwurst, Kathia Nelson, Yufeng Zhang, Reinhard Gruber, Michael A. Pikos, and Ferdinando D’Avenia
3. The Use of Allografts for Bone and Periodontal Regeneration
Alberto Monje, Angel Insua, Michael A. Pikos, Richard J. Miron, and Hom-Lay Wang
4. The Use of Xenografts in Implant Dentistry and Periodontology
Richard J. Miron, Sarah Al-Maawi, Anton Sculean, Michael A. Pikos, Yufeng Zhang, and Shahram Ghanaati
5. Next-Generation Natural Bovine Bone Mineral Grafting Material with Integrated Atelocollagen Type 1
Richard J. Miron, Mustafa Abd El Raouf, Yufeng Zhang, Andrea Grassi, and Ferdinando D’Avenia
6. Synthetic Bone Substitute Materials
Jonathan Du Toit and Howard Gluckman
7. Next-Generation Osteoinductive Synthetic Calcium Phosphates: Osopia
Richard J. Miron, Albert Barroso Panella, Joost de Bruijn, Yufeng Zhang, and Huipin Yuan
8. The Use of Autogenous Dentin Particulate Graft for Alveolar Ridge Preservation and Augmentation Following Tooth Extraction
Itzhak Binderman, Mariusz Duda, Gideon Hallel, and Robert Horowitz
9. Next-Generation Osteoconductive Resorbable Bone Adhesives: Tetranite
George Kay, Michael Brown, Michael A. Pikos, Alan Pollack, Paul Fugazzotto, Bruce R. Donoff, Richard J. Miron, and David L. Cochran
10. 3D Printing Scaffolds for Alveolar Bone Augmentation
Xiaoxin Zhang, Hudi Xu, Yufeng Zhang, and Richard J. Miron
11. Membranes for Guided Tissue and Bone Regeneration
Richard J. Miron, Yufeng Zhang, Jordi Caballé Serrano, Michael A. Pikos, Ferdinando D’Avenia, and Anton Sculean
12. Autogenous Blood-Derived Barrier Membranes: Platelet-Rich Fibrin in Regenerative Dentistry
Richard J. Miron, Alexandre-Amir Aalam, Alina Krivitsky Aalam, Masako Fujioka-Kobayashi, Vincent Guillemette, Fatiha Chandad, Mark Bishara, Gregori Kurtzman, Alain Simonpieri, Yufeng Zhang, Shahram Ghanaati, and Joseph Choukroun
13. Bone Regeneration with Bone Morphogenetic Protein 2
Richard J. Miron, Michael A. Pikos, Yufeng Zhang, Stuart Froum, and Ismael Khouly
14. Enamel Matrix Derivative: Preclinical Biologic Background
Richard J. Miron, Anton Sculean, David L. Cochran, Nikos Donos, James Deschner, Michel Dard, Yufeng Zhang, Adrian Kasaj, Yoshinori Shirakata, and Dieter D. Bosshardt
15. Enamel Matrix Derivative: Clinical Studies
Richard J. Miron, Dieter D. Bosshardt, Stuart Froum, Giovanni Zucchelli, Carlos Nemcovsky, Staale Petter Lyngstadaas, Andreas Stavropoulos, Leonardo Trombelli, Guilio Rasperini, Sřren Jepsen, and Anton Sculean
16. Efficacy of Recombinant Human PDGF and FGF-2 for Regenerative Dentistry
Liwei Zheng and Ye Ling
17. Combination Approaches for Periodontal Regeneration: Biologics, Bone Grafts, and Barrier Membranes
Richard J. Miron, Andreas Stavropoulos, Dimitris Nikolidakis, Nicole B. Arweiler, Ferenc Döri, Yufeng Zhang, Nikos Donos, and Anton Sculean
18. Next-Generation Bone Morphogenetic Protein 9: The Future of Bone Regeneration?
Richard J. Miron, Toshiaki Nakamura, Yoshinori Shirakata, Nikola Saulacic, Kazuyuki Noguchi, Yufeng Zhang, and Masako Fujioka-Kobayashi
19. Osteogain: The Next Generation of Enamel Matrix Derivative
Richard J. Miron, Yoshinori Shirakata, Yufeng Zhang, Benjamin Pippenger, Toshiaki Nakamura, Kazuyuki Noguchi, and Anton Sculean
20. Next-Generation Wound Healing with Hyaluronic Acid
Masako Fujioka-Kobayashi, Meizi Eliezer, Patrick R. Schmidlin, Anton Sculean, and Richard J. Miron
21. Next-Generation Ion Incorporation into Bone Grafts for Bone and Periodontal Regeneration
Yulan Wang, Richard J. Miron, and Yufeng Zhang
22. Next-Generation Use of Gene Therapy for Growth Factor Delivery
Xiaoxin Zhang, Hudi Xu, Richard J. Miron, and Yufeng Zhang
23. Clinical Recommendations and Guidelines for Selecting Biomaterials for Bone and Periodontal Regeneration
Richard J. Miron and Yufeng Zhang
Abbreviations